2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1545
    ACTH (1-17)
    		Agonist
    ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.
    ACTH (1-17)
  • HY-111131
    RY764
    		Agonist
    RY746 is a selective MC4R agonist, with an EC50 of 10 nM. RY764 effectively inhibits food intake and reduces body weight gain in diet-induced obese (DIO) rat models. RY764 can be used for the study of obesity.
    RY764
  • HY-N2307B
    (R)-Lirinidine
    (R)-Lirinidine ((-)-Lirinidine) is an aporphine-type alkaloid found in the flower buds and leaves of Nelumbo nucifera. (R)-Lirinidineand inhibits melanogenesis with an IC50 of 19.3 μM. (R)-Lirinidine exerts cytotoxic effects at 100 μM.
    (R)-Lirinidine
  • HY-P1208A
    PG-931 TFA
    		Agonist
    PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R(IC50=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
    PG-931 TFA
  • HY-P0267A
    Melanotan (MT)-II acetate
    		Agonist
    Melanotan (MT)-II acetate is a melanocortin receptor agonist that crosses the blood-brain barrier. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction.
    Melanotan (MT)-II acetate
  • HY-P1213A
    JKC363 TFA
    		Antagonist
    JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.
    JKC363 TFA
  • HY-P3924
    Agouti-Related Protein (54-82) (human)
    		Inhibitor
    Agouti-Related Protein (54-82) (human) (AGRP (54-82) (human)) is an amino-terminal 54-82 fragment of agouti-related protein (AGRP).
    Agouti-Related Protein (54-82) (human)
  • HY-11073
    MK-0489
    		Agonist
    MK-0489 is an orally active, highly effective, and selective MC4R agonist. MK-0489 exhibits a strong binding affinity (IC50 = 13 nM) and functional agonist activity (EC50 = 4.6 nM) at human MC4R. MK-0489 shows functional activity of 22 nM (EC50) on mouse MC4R and 1.7 μM (EC50) on mouse MC3R. MK-0489 can be used for the study of obesity.
    MK-0489
  • HY-RS08201
    Mc1r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc1r Mouse Pre-designed siRNA Set A
  • HY-RS08214
    Mc5r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc5r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc5r Rat Pre-designed siRNA Set A
  • HY-RS08203
    MC2R Human Pre-designed siRNA Set A
    		Inhibitor

    MC2R Human Pre-designed siRNA Set A contains three designed siRNAs for MC2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC2R Human Pre-designed siRNA Set A
  • HY-P3977
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) can be used for research of a variety of diseases, including cancer, immune diseases, cardiovascular disease.
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
  • HY-P1214A
    γ1-MSH TFA
    		Agonist
    γ1-MSH TFA is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (Ki=1318 nM).
    γ1-MSH TFA
  • HY-RS08211
    Mc4r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc4r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc4r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc4r Rat Pre-designed siRNA Set A
  • HY-19648
    Ebiratide
    Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain.
    Ebiratide
  • HY-P1726A
    MSG606 TFA
    		Antagonist
    MSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH).
    MSG606 TFA
  • HY-RS08207
    Mc3r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc3r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc3r Mouse Pre-designed siRNA Set A
  • HY-153660A
    Bivamelagon hydrochloride
    		Agonist
    Bivamelagon (MC-4R Agonist 2) hydrochloride is an orally active and BBB-penetrable MC4R agonist with EC50 values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a Ki of 65 nM. Bivamelagon hydrochloride can be used for the research of diseases such as obesity and diabetes.
    Bivamelagon hydrochloride
  • HY-168383
    (E/Z)-Resomelagon acetate
    		Agonist
    (E/Z)-Resomelagon acetate is an agonist of melanocortin receptor 1 (MC1R) and MC3R with anti-inflammatory activities. (E/Z)-Resomelagon can be utilized in inflammation research.
    (E/Z)-Resomelagon acetate
  • HY-W267446
    6-Methoxy-4-methylcoumarin
    		Activator 99.00%
    6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo.
    6-Methoxy-4-methylcoumarin
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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